The UKCRC Registered CTU Network’s PeRSEVERE Project team has launched a dedicated website bringing together all its guidance on managing participation changes in clinical trials.

PeRSEVERE focused on participants in clinical trials stopping, reducing or changing their level of involvement.

The project aimed to address the question: how should we design and carry out clinical trials and other research, given that we know some participants will stop participating early?

PeRSEVERE was a collaborative effort, involving representatives of many different clinical trials units and different areas of expertise from across the CTU Network, as well as a patient group.

The team developed high-level principles to guide management of early end of participation in clinical trials and other research studies. Between May and August 2021, they ran a public consultation on the draft principles. The responses to the consultation were used to agree the final principles and associated explanatory guidance.

The PeRSEVERE principles, explanatory guidance, and related resources are all available at https://persevereprinciples.org.